Uji Efektivitas Antihiperglikemik Ekstrak Etanol Bunga Rosella (Hibiscus sabdariffa L) yang di Induksi Sukrosa pada mencit Jantan (Mus musculus)

 Widy Susanti Abdulkadir, Juliyanty Akuba, Muh. Nadzirul Rahman, Sukmawati Damiti

Abstract


Diabetes mellitus is a serious condition characterized by an increase in glucose levels (GDS) ≥ 200 mg/dL due to the body’s inability to produce the hormone insulin effectively. Many plants have antidiabetic properties, including the roselle (Hibiscus sabdariffa L.) flower, which has been rarely studied scientifically. This research aims to determine the most effective dose of ethanol extract of roselle flower for antihyperglycemic activity in male mice induced with a 90% sucrose solution. This research employs the Oral Sucrose Tolerance Test (OSTT) method. Activity tests in mice were conducted on 5 treatment groups: Group I was the negative control (Na-CMC 1% w/v), Group II was the positive control (acarbose), Group III received ethanol extract at a dose of 250 mg/kgBW, Group IV received ethanol extract at dose of 500 mg/kgBW, and Group V received ethanol extract at a dose of 750

Keywords


Antidiabetic, Ethanol Extract, Mice, Roselle,

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References


Hasan, H., Suryadi, A. M. A., &Djufri, Z. Uji aktivitas antidiabetes ekstrak etil asetat daun lamun (Enhalusacoroides) pada mencit (Mus musculus). Journal Syifa Sciences and Clinical Research (JSSCR), 2022, 4(1).

Yosmar, R., Shepany, E., & Fitria, N. A comprehensive analysis of antidiabetic drug interactions in geriatric non-insulin dependent diabetes mellitus patients. Int J Appl Pharm, 2024, 16(1), 62–65.

Soegondo, S., Prodjosudjadi, W., & Setiawati, A. Prevalence and risk factors for microalbuminuria in a cross-sectional study of type-2 diabetic patients in Indonesia: a subset of DEMAND study. Medical Journal of Indonesia, 2009, 18(2), 124–130.

Baehaki, A., Lestari, S. D., &Violita, L. Penggunaan Edible Film yang Ditambahkan Ekstrak Purun Tikus (Eleocharis dulcis) pada Pempek yang Disimpan pada Suhu Ruang. JurnalPengolahan Hasil Perikanan Indonesia, 2020, 23(1), 186–195.

Widianto, E., Santoso, D. B., Kardiman, K., & Nugraha, A. E. (2020). Pemberdayaan masyarakat tentang pemanfaatan tanaman saga (Abrus precatorius L) di Desa Tanahbaru Pakisjaya Karawang. Aksiologiya: Jurnal Pengabdian Kepada Masyarakat, 4(1), 63-69.

Herdiani, N., &Wikurendra, E. A. Aktivitas Antioksidan Ekstrak Kelopak Rosella (Hibiscus sabdariffa Linn.) Dengan Metode DPPH, 2020.

Sulistyoningdyah, F., & Ramayani, L. S. (2017). Skrining Fitokimia Ekstrak Infusa Kulit Petai (Parkia speciosa Hassk). Jurnal Jawara, 4(1), 1-3.

Vershinin, V., Forkosh, H., Ben-Lulu, M., Libman, A., & Pappo, D. Mechanistic insights into the FeCl3-catalyzed oxidative cross-coupling of phenols with 2-aminonaphthalenes. The Journal of Organic Chemistry, 2020. 86(1), 79–90.

Parbuntari, H., Prestica, Y., Gunawan, R., Nurman, M. N., & Adella, F. Preliminary phytochemical screening (qualitative analysis) of cacao leaves (Theobroma cacao L.). Eksakta: BerkalaIlmiahBidang MIPA (E-ISSN: 2549-7464), 19(2), 2018, 40–45.

Manongko, P. S., Sangi, M. S., &Momuat, L. I. Uji senyawa fitokimia dan aktivitas antioksidan tanaman patah tulang (Euphorbia tirucalli L.). JurnalMipa, 2020, 9(2), 64–69.

Vershinin, V., Forkosh, H., Ben-Lulu, M., Libman, A., & Pappo, D. Mechanistic insights into the FeCl3-catalyzed oxidative cross-coupling of phenols with 2-aminonaphthalenes. The Journal of Organic Chemistry, 2020. 86(1), 79–90.

Chamberlain, J. J., Doyle-Delgado, K., Peterson, L., & Skolnik, N. Diabetes technology: review of the 2019 American Diabetes Association standards of medical care in diabetes. Annals of Internal Medicine, 2019, 171(6), 415–420.

Hollander, P. A. Treating Diabetes in the Elderly: A Balanced Approach. Baylor University Medical Center Proceedings, 1997, 10(3), 141–146.

Rodwell, V. W., Bender, D., & Botham, K. M. Harper’s illustrated biochemistry. McGraw-Hill. 2.018

Kato, C. G., Gonçalves, G. de A., Peralta, R. A., Seixas, F. A. V., de Sá-Nakanishi, A. B., Bracht, L., Comar, J. F., Bracht, A., & Peralta, R. M. Inhibition of α‐amylases by condensed and hydrolysable tannins: focus on kinetics and hypoglycemic actions. Enzyme Research, 2017 (1), 5724902.

Dalsgaard, N. B., Gasbjerg, L. S., Hansen, L. S., Hansen, N. L., Stensen, S., Hartmann, B., Rehfeld, J. F., Holst, J. J., Vilsbøll, T., & Knop, F. K. (2021). The role of GLP-1 in the post prandial effects of acarbose in type 2 diabetes. European Journal of Endocrinology, 2021, 184(3), 383–394.

Dianasari, D., &Fajrin, F. A. Uji aktivitas antidiabetes ekstrak air kelopak bunga rosella (Hibiscus sabdariffa L.) pada tikus dengan metode induksi aloksan. Jurnal Farmasi Sains Dan Terapan (Journal of Pharmacy Science and Practice), 2015, 2(1).

Herdiani, N., &Wikurendra, E. A. Aktivitas Antioksidan Ekstrak Kelopak Rosella (Hibiscus sabdariffa Linn.) Dengan Metode DPPH, 2020.

Mentari Putri, M. (2024). Farktor- Farktor yang berhubungan dengan derajat chronic kidney disease (CKD) pada Pasien Diabetess Melitus tipe 2 di RSUD DR. H. Abdul Moeloek Bandar Lampung. 2024.

Yin XiaoXing, Y. X., Zhang YinDi, Z. Y., Wu HaiWei, W. H., Zhu XiAng, Z. X., Zheng XiaoGang, Z. X., Jiang ShaoJun, J. S., Zhuo HaiTong, Z. H., Shen JianPing, S. J., Li LiMin, L. L., & Qiu Jun, Q. J. Protective effects of Astragalus saponin I on early stage of diabetic nephropathy in rats. 2024.

Anggraini, A. Manfaat Antioksidan Daun Salam Terhadap Kadar Glukosa Darah dan Penurunan Apoptosis Neuron di Hippocampus Otak Tikus yang Mengalami Diabetes. Jurnal Medika Hutama, 2020, 2(01 Oktober), 349–355.


DOI: http://dx.doi.org/10.31314/mjk.13.1.67-75.2024

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