Hubungan Durasi Hipertensi Terhadap Pola Elektrokardiogram: Kajian Klinis Untuk Deteksi Dini Perubahan Jantung
Abstract
Hypertension is a major risk factor contributing to cardiovascular disorders, including left ventricular hypertrophy, making early detection through an ECG crucial for preventing complications. This study aimed to assess the relationship between hypertension duration and LVH/RVH findings and the overall interpretation of the ECG.The method used was a clinical experiment with a quantitative approach involving 67 hypertensive patients with disease duration of ≤5 years and >5 years. ECG data were analyzed to identify changes in patterns related to hypertension duration, and the Pearson correlation test was used to assess the relationship between variables. The sample was predominantly adult to elderly and predominantly female, with a relatively balanced distribution of hypertension duration. The analysis revealed a significant negative association between hypertension duration and LVH/RVH findings (r = –0.255; p = 0.038) and a weak but significant positive association between hypertension duration and overall ECG abnormalities (r = 0.285; p = 0.020). This pattern indicates that although cardiac structural and electrical changes tend to increase with hypertension duration, the limited sensitivity of the ECG results in a non-linear relationship. This study concludes that hypertension duration is associated with ECG changes, although the strength is weak, necessitating additional evaluation for a comprehensive cardiac assessment.
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Mills KT, Stefanescu A, He J. The global epidemiology of hypertension. Nat Rev Nephrol. 2020;16(4):223-237. doi:10.1038/s41581-019-0244-2
Brouwers S, Sudano I, Kokubo Y, Sulaica EM. Arterial hypertension. Lancet. 2021;398(10296):249-261. doi:10.1016/S0140-6736(21)00221-X
WHO. Global Report on Hypertension. Vol 01.; 2023.
Pan American Health Organization. World Hypertension Day 2020. Pan American Health Organization. Published 2020. https://www.paho.org/en/campaigns/world-hypertension-day-2020
Mills KT, Bundy JD, Kelly TN, et al. Global disparities of hypertension prevalence and control: a systematic analysis of population-based studies from 90 countries. Circulation. 2016;134(6):441-450.
Mohammed Nawi A, Mohammad Z, Jetly K, et al. The Prevalence and Risk Factors of Hypertension among the Urban Population in Southeast Asian Countries: A Systematic Review and Meta-Analysis. Int J Hypertens. 2021;2021. doi:10.1155/2021/6657003
BKPK. Prevalensi, Dampak, serta Upaya Pengendalian Hipertensi & Diabetes di Indonesia. Kementeri Kesehat. Published online 2023:1-2. https://drive.google.com/file/d/1RGiLjySxNy4gvJLWG1gPTXs7QQRnkS--/view
Dinkes SulSel. Laporan Kinerja Tahun 2023. Published online 2023.
Riskesdas. Laporan Riskesdas 2018 Nasional.pdf. Lemb Penerbit Balitbangkes. Published online 2018.
Bozkurt B, Aguilar D, Deswal A, et al. Contributory Risk and Management of Comorbidities of Hypertension, Obesity, Diabetes Mellitus, Hyperlipidemia, and Metabolic Syndrome in Chronic Heart Failure: A Scientific Statement From the American Heart Association. Circulation. 2016;134(23):e535-e578. doi:10.1161/CIR.0000000000000450
Collaborators GBD 2016 RF. Global, regional, and national comparative risk assessment of 84 behavioural, environmental and occupational, and metabolic risks or clusters of risks, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016. Lancet (London, England). 2017;390(10100):1345. https://pmc.ncbi.nlm.nih.gov/articles/PMC5614451/
Yetis B, Ali S. Left Ventricular Hypertrophy : Etiology-Based Therapeutic Options. Cardiol Ther. 2022;11(2):203-230. doi:10.1007/s40119-022-00260-y
Schumacher K, Kornej J, Shantsila E, Lip GYH. Heart Failure and Stroke. Published online 2018:287-296.
Leache L, Gutiérrez-Valencia M, Finizola RM, et al. Pharmacotherapy for hypertension-induced left ventricular hypertrophy. Cochrane database Syst Rev. 2021;10(10):CD012039. doi:10.1002/14651858.CD012039.pub3
Saheera S. Cardiovascular Changes Associated with Hypertensive Heart Disease and Aging. 2020;29:1-10. doi:10.1177/0963689720920830
Sattar Y, Chhabra L. Electrocardiogram. In: ; 2025.
Bird K, Chan G, Lu H, et al. Assessment of Hypertension Using Clinical Electrocardiogram Features : A First-Ever Review. Assess Hypertens Using Electrocardiogram. 2020;7(December):1-17. doi:10.3389/fmed.2020.583331
Rafie N, Kashou AH, Noseworthy PA. ECG Interpretation : Clinical Relevance , Challenges , and Advances. MDPI. 2021;2:505-513.
Wu Y, Xin B, Wan Q, Ren Y, Jiang W. Heliyon Risk factors and prediction models for cardiovascular complications of hypertension in older adults with machine learning : A cross-sectional study. Heliyon. 2024;10(6):e27941. doi:10.1016/j.heliyon.2024.e27941
Fira S. ECG Profile of Hypertension patients in Outpatient Cardiac Uni. J Ners Indones. 2016;11 No 1.
Taufikurrahman T, Wahid A, Rizany I. Perbedaan Gambaran Ekg Pada Pasien Hipertensi Dengan Lama Riwayat Menderita< 5 Tahun Dan ≥5 Tahun Di Poli Penyakit Dalam Rumah Sakit H. Damanhuri Barabai. Din Kesehat J Kebidanan dan Keperawatan. 2019;10(1):427-439.
Ayu Pratiwi Hasari D. Karakteristik Gambaran EKG Pasien Hipertensi di Rumah Sakit Ibnu Sina Makassar Periode Januari-Juni 2017. Umi Med J. 2019;3(2):71-80.
Puthenpura MM, Sipko J, Sankar PR, et al. Correlating Left Atrial Enlargement and Left Ventricular Hypertrophy on ECG With Echocardiography and Cardiac Magnetic Resonance Imaging. J Am Heart Assoc. 2025;14(6):e037772. doi:10.1161/JAHA.124.037772
Evangelos Oikonomou. Diagnostic performance of electrocardiographic criteria in echocardiographic diagnosis of different patterns of left ventricular hypertrophy. Oikonomou Theofilis Contrib Equal to this Work This. 2019;(August):1-9. doi:10.1111/anec.12728
Franz H. Messerli. The Transition From Hypertension to Heart Failure. JACC Hear Fail. 2017;5(8). doi:10.1016/j.jchf.2017.04.012
Ying JC, Li PC, Yu QWJ. Comparative efficacy of different types of antihypertensive drugs in reversing left ventricular hypertrophy as determined with echocardiography in hypertensive patients : A network meta-analysis of randomized controlled trials. J Clin Hypertens. 2020;(July):2175-2183. doi:10.1111/jch.14047
Liu CW, Wu FH, Hu YL, Pan RH, Lin CH. Left ventricular hypertrophy detection using electrocardiographic signal. Sci Rep. Published online 2023:1-13. doi:10.1038/s41598-023-28325-5
Zhao X, Huang G, Wu L, et al. Deep learning assessment of left ventricular hypertrophy based on electrocardiogram. Front Cardiovasc Med. Published online 2022. doi:10.3389/fcvm.2022.952089
Angelaki E, Marketou M, Barmparis G, et al. Detection of left ventricular hypertrophy on the ECG through machine learning with a focus on obesity ESC Congress 2022 – Barcelona , Spain. 2022;(August):2772.
Huang J, Tseng C, Huang W, et al. Comparison of machine learning and conventional criteria in detecting left ventricular hypertrophy and prognosis with electrocardiography. Eur Hear J - Digit Heal. 2025;6(2):252-260. doi:10.1093/ehjdh/ztaf003
Zipes DP. Braunwald’s Heart Disease e-Book: A Textbook of Cardiovascular Medicine. Elsevier Health Sciences; 2018.
Amar J, Touront N, Ciron AM, Pendaries C. Interactions between hypertension and inflammatory tone and the effect on blood pressure and outcomes in patients with. J Clin Hypertens. 2021;(November 2020):238-244. doi:10.1111/jch.14137
Díez J, Butler J. Growing heart failure burden of hypertensive heart disease: a call to action. Hypertension. 2023;80(1):13-21.
Tin YY, Chan LP, Sung JG, Leung SY, Hui EMT, Leung MKW. Prevalence of major electrocardiographic abnormalities in patients with hypertension in a primary care clinic in Hong Kong. BMC Cardiovasc Disord. 2022;22(1):1-9. doi:10.1186/s12872-022-02662-1
Rankinen J, Haataja P, Lyytikäinen L-P, et al. Prevalence and long-term prognostic implications of prolonged QRS duration in left ventricular hypertrophy: a population-based observational cohort study. BMJ Open. 2022;12(2):e053477. doi:10.1136/bmjopen-2021-053477
Mancia G. 2023 ESH Guidelines for the management of arterial hypertension The Task Force for the management of arterial hypertension of the European Society of Hypertension Endorsed by the International Society of Hypertension ( ISH ) and the European Renal Associa. ESH Guidel 20232023. 2023;41(12).
Fan J, Wang H, Zhang Y, Ma C, Zhou B. Myocardial work alterations with progressive left ventricular hypertrophy in patients with hypertension. J Clin Hypertens (Greenwich). 2024;26(9):1045-1053. doi:10.1111/jch.14855
Faggiano A. Do We Need New Electrocardiographic Criteria for Left Ventricular Hypertrophy ? The Case of the Peguero – Lo Presti Criterion . A Narrative Review. Am J Hypertens. 2024;(December 2023):155-162.
Groot LE De, Isabella DL, Zijlstra F. Optimized electrocardiographic criteria for the detection of left ventricular hypertrophy in obesity patients. 2020;(December 2019):483-490. doi:10.1002/clc.23333
Huang H, Fu L, Ruan Q, You Z, Yan L. Segmental and global myocardial work in hypertensive patients with different left ventricular geometry. Cardiovasc Ultrasound. Published online 2023:1-11. doi:10.1186/s12947-023-00310-y
Manzi MV, Kim HM, Hwang I, Choi H, Yoon YE, Cho G. Prognostic implication of left ventricular hypertrophy regression after antihypertensive therapy in patients with hypertension. Front Cardiovasc Med. 2022;(December):1-13. doi:10.3389/fcvm.2022.1082008
Letmi SO, Yanni M, Revilla G. Hubungan Hipertrofi Ventrikel Kiri pada Elektrokardiogram Peguero-Lo Presti Dengan Ekokardiografi pada Hipertensi. J Ilmu Kesehat Indones. 2023;4:59-66.
Verheule S, Schotten U. Electrophysiological Consequences of Cardiac Fibrosis. MDPI. 2021;(Figure 1).
Wang BX. Diagnosis and Management of Hypertensive Heart Disease : Incorporating 2023 European Society of Hypertension and 2024 European Society of Cardiology Guideline Updates. Cardiovacular Dev Dis. Published online 2025:1-19.
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